| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 |
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| Ligand | BDBM50332085 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_687739 (CHEMBL1291185) |
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| IC50 | 270±n/a nM |
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| Citation |  Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Tóth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett20:7303-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 8 |
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| Name: | Mitogen-activated protein kinase 8 |
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| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 48297.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
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| Residue: | 427 |
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| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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| BDBM50332085 |
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| n/a |
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| Name | BDBM50332085 |
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| Synonyms: | CHEMBL1288099 | N-(2-(4H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(quinolin-5-yl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N5OS |
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| Mol. Mass. | 335.383 |
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| SMILES | O=C(Cc1cccc2ncccc12)Nc1ccsc1-c1nnc[nH]1 |
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| Structure | 
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