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TargetMitogen-activated protein kinase 14
LigandBDBM50332086
Substrate/Competitorn/a
Meas. Tech.ChEMBL_687746 (CHEMBL1291192)
IC50>50000±n/a nM
Citation Hom, RKBowers, SSealy, JMTruong, APProbst, GDNeitzel, MLNeitz, RJFang, LBrogley, LWu, JKonradi, AWSham, HLTóth, GPan, HYao, NArtis, DRQuinn, KSauer, JMPowell, KRen, ZBard, FYednock, TAGriswold-Prenner, I Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett20:7303-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50332086
n/a
NameBDBM50332086
Synonyms:2-(isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide | CHEMBL1288100 | US9796706, Compound 48
TypeSmall organic molecule
Emp. Form.C18H13N3OS2
Mol. Mass.351.445
SMILESO=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: