| Reaction Details |
|---|
 | Report a problem with these data |
| Target | NAD(P)H dehydrogenase [quinone] 1 |
|---|
| Ligand | BDBM50332181 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_687952 (CHEMBL1291624) |
|---|
| IC50 | 40000±n/a nM |
|---|
| Citation |  Nolan, KA; Caraher, MC; Humphries, MP; Bettley, HA; Bryce, RA; Stratford, IJ In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett20:7331-6 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| NAD(P)H dehydrogenase [quinone] 1 |
|---|
| Name: | NAD(P)H dehydrogenase [quinone] 1 |
|---|
| Synonyms: | Azoreductase | DIA4 | DT-diaphorase | Menadione reductase | NAD(P)H:quinone oxidoreductase 1 | NMOR1 | NQO1 | NQO1_HUMAN | Phylloquinone reductase | QR1 | Quinone Reductase 1 | Quinone reductase 1) |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 30874.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 274 |
|---|
| Sequence: | MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKL
KDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQFPLQWFGVPAILKGWFERV
FIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFC
GFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMK
KEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
|
|
|
|---|
| BDBM50332181 |
|---|
| n/a |
|---|
| Name | BDBM50332181 |
|---|
| Synonyms: | 2-(4-Methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile | CHEMBL1288165 | NSC-332172 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19NO4 |
|---|
| Mol. Mass. | 325.3585 |
|---|
| SMILES | COc1ccc(cc1)C(=C/c1cc(OC)c(OC)c(OC)c1)\C#N |
|---|
| Structure | 
|
|---|
Search and Browse
