| Reaction Details |
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 | Report a problem with these data |
| Target | Matrilysin |
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| Ligand | BDBM50332283 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_686067 (CHEMBL1292823) |
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| IC50 | >40000±n/a nM |
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| Citation |  Girijavallabhan, VM; Chen, L; Dai, C; Feltz, RJ; Firmansjah, L; Li, D; Kim, SH; Kozlowski, JA; Lavey, BJ; Kosinski, A; Piwinski, JJ; Popovici-Muller, J; Rizvi, R; Rosner, KE; Shankar, BB; Shih, NY; Siddiqui, MA; Tong, L; Wong, MK; Yang, DY; Yang, L; Yu, W; Zhou, G; Guo, Z; Orth, P; Madison, V; Bian, H; Lundell, D; Niu, X; Shah, H; Sun, J; Umland, S Novel TNF-a converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases. Bioorg Med Chem Lett20:7283-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrilysin |
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| Name: | Matrilysin |
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| Synonyms: | MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29681.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09237 |
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| Residue: | 267 |
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| Sequence: | MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL
PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF
APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD
PQNFKLSQDDIKGIQKLYGKRSNSRKK
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| BDBM50332283 |
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| n/a |
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| Name | BDBM50332283 |
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| Synonyms: | (R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(pyridin-3-ylethynyl)imidazolidine-2,4-dione | CHEMBL1287851 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16N4O4 |
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| Mol. Mass. | 376.3654 |
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| SMILES | COc1ccc2CN(C[C@]3(NC(=O)NC3=O)C#Cc3cccnc3)C(=O)c2c1 |r| |
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| Structure | 
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