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TargetCannabinoid receptor 1
LigandBDBM50332895
Substrate/Competitorn/a
Meas. Tech.ChEMBL_694005
Ki 90.7±n/a nM
Citation Silvestri RLigresti ALa Regina GPiscitelli FGatti VLavecchia ABrizzi APasquini SAllarà MFantini NCarai MABigogno CRozio MGSinisi RNovellino EColombo GDi Marzo VDondio GCorelli F Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands. Eur J Med Chem 45:5878-86 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50332895
n/a
NameBDBM50332895
Synonyms:1-(2,4-Difluorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(3,3-dimethylbutyl)-4-methyl-1H-pyrazole-3-carboxamide | CHEMBL1631301
TypeSmall organic molecule
Emp. Form.C23H28F2N4O
Mol. Mass.414.4914
SMILESCc1ccc(C)n1-c1c(C)c(nn1-c1ccc(F)cc1F)C(=O)NCCC(C)(C)C |(.88,1.17,;.41,-.3,;-1.04,-.77,;-1.05,-2.3,;.42,-2.78,;.89,-4.25,;1.33,-1.55,;2.86,-1.48,;3.4,-.04,;2.57,1.26,;4.92,-.12,;5.33,-1.59,;4.06,-2.44,;4.06,-3.99,;2.73,-4.76,;2.73,-6.3,;4.06,-7.08,;4.06,-8.62,;5.4,-6.3,;5.39,-4.75,;6.74,-3.97,;5.74,1.21,;5.03,2.55,;7.29,1.15,;8.01,-.2,;9.55,-.25,;10.28,-1.61,;9.46,-2.92,;11.82,-1.67,;10.82,-3.05,)|
Structure
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