| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate kinase |
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| Ligand | BDBM50332929 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_694285 (CHEMBL1637647) |
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| Ki | 4500±n/a nM |
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| Citation |  Familiar, O; Munier-Lehmann, H; Aínsa, JA; Camarasa, MJ; Pérez-Pérez, MJ Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone. Eur J Med Chem45:5910-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate kinase |
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| Name: | Thymidylate kinase |
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| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22636.29 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_208218 |
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| Residue: | 214 |
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| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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| BDBM50332929 |
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| n/a |
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| Name | BDBM50332929 |
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| Synonyms: | ((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-tetrahydrofuran-2-yl)methyl dihydrogen phosphate | (R)-1-((4S,5R)-4-Hydroxy-5-methylphosphate-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | 2'-deoxythymidine monophosphate | CHEMBL394429 | Phosphoric acid mono-[3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester | THYMIDINE-5'-MONOPHOSPHATE | US11111252, Compound TMP | thymidine monophosphate | thymidine-5'-phosphate |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15N2O8P |
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| Mol. Mass. | 322.2085 |
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| SMILES | Cc1cn([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)c(=O)[nH]c1=O |r| |
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| Structure | 
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