| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate kinase |
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| Ligand | BDBM50332937 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_694285 (CHEMBL1637647) |
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| Ki | 570±n/a nM |
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| Citation |  Familiar, O; Munier-Lehmann, H; Aínsa, JA; Camarasa, MJ; Pérez-Pérez, MJ Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone. Eur J Med Chem45:5910-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate kinase |
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| Name: | Thymidylate kinase |
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| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22636.29 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_208218 |
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| Residue: | 214 |
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| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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| BDBM50332937 |
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| n/a |
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| Name | BDBM50332937 |
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| Synonyms: | 1-[4-(2,2-Dioxo-4,5-dihydro-3H-2lambda-6-thia-1,2a-diaza-acenaphthylen-1-yl)-but-2-enyl]-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL1631398 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N4O4S |
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| Mol. Mass. | 388.441 |
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| SMILES | Cc1cn(C\C=C\CN2c3cccc4CCCN(c34)S2(=O)=O)c(=O)[nH]c1=O |
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| Structure | 
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