| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Macrophage metalloelastase |
|---|
| Ligand | BDBM50332947 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_694547 (CHEMBL1635956) |
|---|
| Ki | 8±n/a nM |
|---|
| Citation |  Attolino, E; Calderone, V; Dragoni, E; Fragai, M; Richichi, B; Luchinat, C; Nativi, C Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). Eur J Med Chem45:5919-25 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Macrophage metalloelastase |
|---|
| Name: | Macrophage metalloelastase |
|---|
| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54012.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P39900 |
|---|
| Residue: | 470 |
|---|
| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
|
|
|
|---|
| BDBM50332947 |
|---|
| n/a |
|---|
| Name | BDBM50332947 |
|---|
| Synonyms: | (S)-2-(N-(2,3-dihydroxypropyl)-4-methoxyphenylsulfonamido)-N-hydroxyacetamide | CHEMBL1632637 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H18N2O7S |
|---|
| Mol. Mass. | 334.346 |
|---|
| SMILES | COc1ccc(cc1)S(=O)(=O)N(C[C@H](O)CO)CC(=O)NO |r| |
|---|
| Structure | 
|
|---|
Search and Browse
