Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMetabotropic glutamate receptor 2
LigandBDBM50332983
Substrate/Competitorn/a
Meas. Tech.ChEMBL_696216 (CHEMBL1639369)
IC50 7±n/a nM
Citation Woltering, TJWichmann, JGoetschi, EKnoflach, FBallard, TMHuwyler, JGatti, S Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists. Bioorg Med Chem Lett20:6969-74 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 2
Name:Metabotropic glutamate receptor 2
Synonyms:GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2
Type:Enzyme
Mol. Mass.:95584.88
Organism:Homo sapiens (Human)
Description:Q14416
Residue:872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50332983
n/a
NameBDBM50332983
Synonyms:4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7,8-bis(trifluoromethyl)-1H-benzo[b][1,4]diazepin-2(3H)-one | CHEMBL1629860
TypeSmall organic molecule
Emp. Form.C24H17F6N3O
Mol. Mass.477.4017
SMILESCc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(c(cc2NC(=O)C1)C(F)(F)F)C(F)(F)F |t:16|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: