| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase |
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| Ligand | BDBM19149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_692926 (CHEMBL1637566) |
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| IC50 | 100±n/a nM |
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| Citation |  Dow, GS; Chen, Y; Andrews, KT; Caridha, D; Gerena, L; Gettayacamin, M; Johnson, J; Li, Q; Melendez, V; Obaldia, N; Tran, TN; Kozikowski, AP Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. Antimicrob Agents Chemother52:3467-77 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase |
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| Name: | Histone deacetylase |
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| Synonyms: | Histone Deacetylase (pfHDAC-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51371.91 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | Assays were performed using recombinant pfHDAC-1 expressed and purified from S2 insect cells. |
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| Residue: | 449 |
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| Sequence: | MSNRKKVAYFHDPDIGSYYYGAGHPMKPQRIRMTHSLIVSYNLYKYMEVYRPHKSDVNEL
TLFHDYEYIDFLSSISLENYREFTYQLKRFNVGEATDCPVFDGLFQFQQSCAGASIDGAS
KLNHHCADICVNWSGGLHHAKMSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDG
VEEAFYVTHRVMTVSFHKFGDYFPGTGDITDVGVNHGKYYSVNVPLNDGMTDDAFVDLFK
VVIDKCVQTYRPGAIIIQCGADSLTGDRLGRFNLTIKGHARCVEHVRSYNIPLLVLGGGG
YTIRNVSRCWAYETGVVLNKHHEMPDQISLNDYYDYYAPDFQLHLQPSNIPNYNSPEHLS
RIKMKIAENLRHIEHAPGVQFSYVPPDFFNSDIDDESDKNQYELKDDSGGGRAPGTRAKE
HSTTHHLRRKNYDDDFFDLSDRDQSIVPY
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| BDBM19149 |
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| n/a |
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| Name | BDBM19149 |
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| Synonyms: | CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA | US10011611, SAHA | US10188756, Compound SAHA | US11207431, SAHA | US11505523, Compound SAHA | US9115116, SAHA | US9353061, SAHA | US9428447, SAHA | US9695181, Vorinostat | Vorinostat | Zolinza | cid_5311 | suberoylanilide hydroxamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C14H20N2O3 |
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| Mol. Mass. | 264.3202 |
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| SMILES | ONC(=O)CCCCCCC(=O)Nc1ccccc1 |
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| Structure | 
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