Ki Summary

Reaction Details

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Target

Beta-lactamase

Ligand

BDBM50022788

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_693673 (CHEMBL1637941)

IC50

4±n/a nM

Citation

Zioga, A; Whichard, JM; Kotsakis, SD; Tzouvelekis, LS; Tzelepi, E; Miriagou, V CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. Antimicrob Agents Chemother53:1256-9 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Beta-lactamase

Name:

Beta-lactamase

Synonyms:

Class C beta-lactamase CMY-36 | LAT-2 | LAT-2 b-lactamase

Type:

PROTEIN

Mol. Mass.:

42045.45

Organism:

Klebsiella pneumoniae

Description:

ChEMBL_693673

Residue:

381

Sequence:

MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYY
FTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKQ
WQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGA
LAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYREGKPVHVSPGQLDAEA
YGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKA
DSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLA
NKSYPNPVRVEAAWRILEKLQ

BDBM50022788

n/a

Name

BDBM50022788

Synonyms:

(2S,5R,6R)-6-(3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (2S,5R,6R)-6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 6-{[3-(2-Chloro-phenyl)-5-methyl-isoxazole-4-carbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | CHEMBL891 | CLOXAPEN | TEGOPEN | cloxacillin

Type

Small organic molecule

Emp. Form.

C19H18ClN3O5S

Mol. Mass.

435.881

SMILES

Cc1onc(c1C(=O)N[C@H]1[C@H]2SC(C)(C)[C@@H](N2C1=O)C(O)=O)-c1ccccc1Cl |r|

Structure