Ki Summary

Reaction Details

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Target

Beta-lactamase

Ligand

BDBM50240480

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_693673 (CHEMBL1637941)

IC50

6±n/a nM

Citation

Zioga, A; Whichard, JM; Kotsakis, SD; Tzouvelekis, LS; Tzelepi, E; Miriagou, V CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. Antimicrob Agents Chemother53:1256-9 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Beta-lactamase

Name:

Beta-lactamase

Synonyms:

Class C beta-lactamase CMY-36 | LAT-2 | LAT-2 b-lactamase

Type:

PROTEIN

Mol. Mass.:

42045.45

Organism:

Klebsiella pneumoniae

Description:

ChEMBL_693673

Residue:

381

Sequence:

MMKKSLCCALLLTASFSTFAAAKTEQQIADIVNRTITPLMQEQAIPGMAVAVIYQGKPYY
FTWGKADIANNHPVTQQTLFELGSVSKTFNGVLGGDCIARGEIKLSDPVTKYWPELTGKQ
WQGIRLLHLATYTAGGLPLQIPDDVRDKAALLHFYQNWQPQWTPGAKRLYANSSIGLFGA
LAVKPSGMSYEEAMTRRVLQPLKLAHTWITVPENEQKDYAWGYREGKPVHVSPGQLDAEA
YGVKSSVIDMARWVQANMDASHVQEKTLQQGIALAQSRYWRIGDMYQGLGWEMLNWPLKA
DSIINGSDSKVALAALPAVEVNPPAPAVKASWVHKTGSTGGFGSYVAFVPEKNLGIVMLA
NKSYPNPVRVEAAWRILEKLQ

BDBM50240480

n/a

Name

BDBM50240480

Synonyms:

(2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate | (2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate(aztreonam) | 2-[1-(2-Amino-thiazol-4-yl)-1-((2S,3S)-2-methyl-4-oxo-1-sulfo-azetidin-3-ylcarbamoyl)-meth-(Z)-ylideneaminooxy]-2-methyl-propionic acid | AZTREONAM | Azactam | Azetreonam | CHEMBL158 | SQ-26776

Type

Small organic molecule

Emp. Form.

C13H17N5O8S2

Mol. Mass.

435.433

SMILES

C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\c2csc(N)n2)C(=O)N1S(O)(=O)=O |r|

Structure