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TargetClass A carbapenemase KPC-2
LigandBDBM50021954
Substrate/Competitorn/a
Meas. Tech.ChEMBL_696792
Ki 167000±n/a nM
Citation Papp-Wallace KMTaracila MHornick JMHujer AMHujer KMDistler AMEndimiani ABonomo RA Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase. Antimicrob Agents Chemother 54:2867-77 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Class A carbapenemase KPC-2
Name:Class A carbapenemase KPC-2
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:31116.99
Organism:Escherichia coli
Description:ChEMBL_696792
Residue:293
Sequence:
MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYR
AEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAE
LSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTS
SPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVY
GTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
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  Blast E-value cutoff:
BDBM50021954
n/a
NameBDBM50021954
Synonyms:(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam) | CHEMBL403 | CP-45,899 | SULBACTAM | UNASYN | US9120808, Sulbactam sodium salt
TypeSmall organic molecule
Emp. Form.C8H11NO5S
Mol. Mass.233.242
SMILESCC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O |r|
Structure
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