Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM50333148 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_701318 (CHEMBL1648938) |
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IC50 | 100±n/a nM |
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Citation | Samadi, A; Valderas, C; de los Ríos, C; Bastida, A; Chioua, M; González-Lafuente, L; Colmena, I; Gandía, L; Romero, A; Del Barrio, L; Martín-de-Saavedra, MD; López, MG; Villarroya, M; Marco-Contelles, J Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles. Bioorg Med Chem19:122-33 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_BOVIN | ACHE | Acetylcholinesterase (AChE) | Acetylcholinesterase precursor |
Type: | Enzyme |
Mol. Mass.: | 67659.62 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 613 |
Sequence: | MRPPWCPLHTPSLTPPLLLLLFLIGGGAEAEGPEDPELLVMVRGGRLRGLRLMAPRGPVS
AFLGIPFAEPPVGPRRFLPPEPKRPWPGVLNATAFQSVCYQYVDTLYPGFEGTEMWNPNR
ELSEDCLYLNVWTPYPRPSSPTPVLVWIYGGGFYSGASSLDVYDGRFLTQAEGTVLVSMN
YRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVG
MHLLSPPSRGLFHRAVLQSGAPNGPWATVGVGEARRRATLLARLVGCPPGGAGGNDTELV
ACLRARPAQDLVDHEWRVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGV
VKDEGSYFLVYGAPGFSKDNESLISRAQFLAGVRVGVPQASDLAAEAVVLHYTDWLHPED
PARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLSWPLWMGVPHGYE
IEFIFGLPLEPSLNYTIEERTFAQRLMRYWANFARTGDPNDPRDPKAPQWPPYTAGAQQY
VSLNLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQ
FDHYSKQDRCSDL
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BDBM50333148 |
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n/a |
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Name | BDBM50333148 |
Synonyms: | 5-Amino-2-(dimethylamino)-6,7,8,9-tetrahydrobenzo[1,8-b]-naphthyridine-3-carbonitrile | CHEMBL1644721 |
Type | Small organic molecule |
Emp. Form. | C15H17N5 |
Mol. Mass. | 267.329 |
SMILES | CN(C)c1nc2nc3CCCCc3c(N)c2cc1C#N |
Structure |
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