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TargetG protein-coupled receptor 44
LigandBDBM50333496
Substrate/Competitorn/a
Meas. Tech.ChEMBL_699224
Ki 1.9±n/a nM
Citation Simard DLeblanc YBerthelette CZaghdane MHMolinaro CWang ZGallant MLau SThao THamel MStocco RSawyer NSillaots SGervais FHoule RLévesque JF Azaindoles as potent CRTH2 receptor antagonists. Bioorg Med Chem Lett 21:841-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
G protein-coupled receptor 44
Name:G protein-coupled receptor 44
Synonyms:CD_antigen=CD294 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | G-protein coupled receptor 44 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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  Blast E-value cutoff:
BDBM50333496
n/a
NameBDBM50333496
Synonyms:(R)-2-(8-(4-fluoro-N-methylphenylsulfonamido)-2-(4-fluorophenyl)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid | CHEMBL1641810
TypeSmall organic molecule
Emp. Form.C26H23F2N3O4S
Mol. Mass.511.54
SMILESCN([C@@H]1CCc2c(CC(O)=O)c3ccc(nc3n2C1)-c1ccc(F)cc1)S(=O)(=O)c1ccc(F)cc1 |r|
Structure
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