| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
|---|
| Ligand | BDBM50333708 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_700443 (CHEMBL1647982) |
|---|
| EC50 | >30000±n/a nM |
|---|
| Citation |  Tyagarajan, S; Chakravarty, PK; Park, M; Zhou, B; Herrington, JB; Ratliff, K; Bugianesi, RM; Williams, B; Haedo, RJ; Swensen, AM; Warren, VA; Smith, M; Garcia, M; Kaczorowski, GJ; McManus, OB; Lyons, KA; Li, X; Madeira, M; Karanam, B; Green, M; Forrest, MJ; Abbadie, C; McGowan, E; Mistry, S; Jochnowitz, N; Duffy, JL A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain. Bioorg Med Chem Lett21:869-73 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nuclear receptor subfamily 1 group I member 2 |
|---|
| Name: | Nuclear receptor subfamily 1 group I member 2 |
|---|
| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
|---|
| Type: | Nuclear receptor |
|---|
| Mol. Mass.: | 49774.77 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75469 |
|---|
| Residue: | 434 |
|---|
| Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
|
|
|
|---|
| BDBM50333708 |
|---|
| n/a |
|---|
| Name | BDBM50333708 |
|---|
| Synonyms: | CHEMBL1643735 | N-tert-butyl-2-(1-(2-(tert-butylamino)-2-oxoethyl)-2-(4-(trifluoromethoxy)phenyl)-1H-indol-5-yl)-2-methylpropanamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H36F3N3O3 |
|---|
| Mol. Mass. | 531.6096 |
|---|
| SMILES | CC(C)(C)NC(=O)Cn1c(cc2cc(ccc12)C(C)(C)C(=O)NC(C)(C)C)-c1ccc(OC(F)(F)F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
