| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 1 group I member 2 |
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| Ligand | BDBM50333724 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_700443 (CHEMBL1647982) |
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| EC50 | 10760±n/a nM |
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| Citation |  Tyagarajan, S; Chakravarty, PK; Park, M; Zhou, B; Herrington, JB; Ratliff, K; Bugianesi, RM; Williams, B; Haedo, RJ; Swensen, AM; Warren, VA; Smith, M; Garcia, M; Kaczorowski, GJ; McManus, OB; Lyons, KA; Li, X; Madeira, M; Karanam, B; Green, M; Forrest, MJ; Abbadie, C; McGowan, E; Mistry, S; Jochnowitz, N; Duffy, JL A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain. Bioorg Med Chem Lett21:869-73 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 1 group I member 2 |
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| Name: | Nuclear receptor subfamily 1 group I member 2 |
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| Synonyms: | NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1 |
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| Type: | Nuclear receptor |
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| Mol. Mass.: | 49774.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75469 |
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| Residue: | 434 |
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| Sequence: | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
GCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLL
PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
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| BDBM50333724 |
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| n/a |
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| Name | BDBM50333724 |
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| Synonyms: | 2-(2-(3,5-bis(trifluoromethyl)phenyl)-1-(2-(tert-butylamino)-2-oxoethyl)-1H-indol-5-yl)-N-tert-butyl-2-methylpropanamide | CHEMBL1643730 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H35F6N3O2 |
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| Mol. Mass. | 583.6082 |
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| SMILES | CC(C)(C)NC(=O)Cn1c(cc2cc(ccc12)C(C)(C)C(=O)NC(C)(C)C)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F |
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| Structure | 
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