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TargetProstaglandin D2 receptor 2
LigandBDBM50333848
Substrate/Competitorn/a
Meas. Tech.ChEMBL_699801 (CHEMBL1645647)
Ki 1.6±n/a nM
Citation Gallant, MBeaulieu, CBerthelette, CColucci, JCrackower, MADalton, CDenis, DDucharme, YFriesen, RWGuay, DGervais, FGHamel, MHoule, RKrawczyk, CMKosjek, BLau, SLeblanc, YLee, EELevesque, JFMellon, CMolinaro, CMullet, WO'Neill, GPO'Shea, PSawyer, NSillaots, SSimard, DSlipetz, DStocco, RSørensen, DTruong, VLWong, EWu, JZaghdane, HWang, Z Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases. Bioorg Med Chem Lett21:288-93 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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BDBM50333848
n/a
NameBDBM50333848
Synonyms:(R)-2-(7-(4-fluoro-N-pentylphenylsulfonamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid | CHEMBL1643787
TypeSmall organic molecule
Emp. Form.C25H29FN2O4S
Mol. Mass.472.572
SMILESCCCCCN([C@@H]1CCc2c(CC(O)=O)c3ccccc3n2C1)S(=O)(=O)c1ccc(F)cc1 |r|
Structure
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