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TargetThioredoxin reductase 1, cytoplasmic
LigandBDBM50333880
Substrate/Competitorn/a
Meas. Tech.ChEMBL_700048 (CHEMBL1646825)
IC50 4406±n/a nM
Citation Sorrentino, FKarioti, AGratteri, PRigobello, MPScutari, GMessori, LBindoli, AChioccioli, MGabbiani, CBergonzi, MCBilia, AR Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones. Bioorg Med Chem19:631-41 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thioredoxin reductase 1, cytoplasmic
Name:Thioredoxin reductase 1, cytoplasmic
Synonyms:NADPH-dependent thioredoxin reductase | TR | TRXR1_RAT | Thioredoxin reductase TR1 | Trxr1 | Txnrd1
Type:PROTEIN
Mol. Mass.:54519.34
Organism:Rattus norvegicus
Description:ChEMBL_589950
Residue:498
Sequence:
MNDSKDAPKSYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCV
NVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVAL
REKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISS
DDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHM
EEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTI
GLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGG
STVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNK
CYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFT
TLSVTKRSGGDILQSGCG
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  Blast E-value cutoff:
BDBM50333880
n/a
NameBDBM50333880
Synonyms:CHEMBL1614664 | Hypericin | Pseudohypericin
TypeSmall organic molecule
Emp. Form.C30H16O9
Mol. Mass.520.4426
SMILESCc1cc(O)c2c3c1c1c(CO)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O
Structure
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