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TargetThioredoxin reductase 1, cytoplasmic
LigandBDBM50005886
Substrate/Competitorn/a
Meas. Tech.ChEMBL_700048 (CHEMBL1646825)
IC50 185000±n/a nM
Citation Sorrentino, FKarioti, AGratteri, PRigobello, MPScutari, GMessori, LBindoli, AChioccioli, MGabbiani, CBergonzi, MCBilia, AR Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones. Bioorg Med Chem19:631-41 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thioredoxin reductase 1, cytoplasmic
Name:Thioredoxin reductase 1, cytoplasmic
Synonyms:NADPH-dependent thioredoxin reductase | TR | TRXR1_RAT | Thioredoxin reductase TR1 | Trxr1 | Txnrd1
Type:PROTEIN
Mol. Mass.:54519.34
Organism:Rattus norvegicus
Description:ChEMBL_589950
Residue:498
Sequence:
MNDSKDAPKSYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCV
NVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVAL
REKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISS
DDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHM
EEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTI
GLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGG
STVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNK
CYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFT
TLSVTKRSGGDILQSGCG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50005886
n/a
NameBDBM50005886
Synonyms:1,8-Dihydroxy-3-methoxy-6-methylanthraquinone | 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione | CHEMBL42624 | Physcione | physcion
TypeSmall organic molecule
Emp. Form.C16H12O5
Mol. Mass.284.2635
SMILESCOc1cc(O)c2C(=O)c3c(O)cc(C)cc3C(=O)c2c1
Structure
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