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TargetThioredoxin reductase 2, mitochondrial
LigandBDBM50085551
Substrate/Competitorn/a
Meas. Tech.ChEMBL_700049 (CHEMBL1646826)
IC50>200000±n/a nM
Citation Sorrentino, FKarioti, AGratteri, PRigobello, MPScutari, GMessori, LBindoli, AChioccioli, MGabbiani, CBergonzi, MCBilia, AR Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones. Bioorg Med Chem19:631-41 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thioredoxin reductase 2, mitochondrial
Name:Thioredoxin reductase 2, mitochondrial
Synonyms:TRXR2_RAT | Trxr2 | Txnrd2
Type:PROTEIN
Mol. Mass.:56441.28
Organism:Rattus norvegicus
Description:ChEMBL_700049
Residue:525
Sequence:
MAAIVAALRGSSGRFRPQTRVLTRGTRGAAGAASAAGGQQNFDLLVIGGGSGGLACAKEA
AQLGRKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAQHYGWEVA
QPVQHNWKAMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVNEHTVHGVDKAGKVTQ
LSAKHIVIATGGRPKYPTQVKGALEHGITSDDIFWLKESPGKTLVVGASYVALECAGFLT
GIGLDTTVMMRSVPLRGFDQQMASLVTEHMESHGTRFLKGCVPSLIRKLPTNQLQVTWED
LASGKEDVGTFDTVLWAIGRVPETRNLNLEKAGVNTNPKNQKIIVDAQEATSVPHIYAIG
DVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMNYSNVPTTVFTPLEYGCVGLSEEEAVAL
HGQEHIEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFA
LGIQCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLDPTVTGCG
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  Blast E-value cutoff:
BDBM50085551
n/a
NameBDBM50085551
Synonyms:1,8-Dihydroxy-3-hydroxymethyl-anthraquinone | 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione | CHEMBL40275 | aloe emodin | aloe-emodin | cid_10207
TypeSmall organic molecule
Emp. Form.C15H10O5
Mol. Mass.270.2369
SMILESOCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
Structure
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