| Reaction Details |
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 | Report a problem with these data |
| Target | Glutathione reductase |
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| Ligand | BDBM50060874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_700053 (CHEMBL1646830) |
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| IC50 | 3670±n/a nM |
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| Citation |  Sorrentino, F; Karioti, A; Gratteri, P; Rigobello, MP; Scutari, G; Messori, L; Bindoli, A; Chioccioli, M; Gabbiani, C; Bergonzi, MC; Bilia, AR Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones. Bioorg Med Chem19:631-41 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutathione reductase |
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| Name: | Glutathione reductase |
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| Synonyms: | GLR1 | GSHR_YEAST |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53448.83 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_700053 |
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| Residue: | 483 |
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| Sequence: | MLSATKQTFRSLQIRTMSTNTKHYDYLVIGGGSGGVASARRAASYGAKTLLVEAKALGGT
CVNVGCVPKKVMWYASDLATRVSHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLN
GIYQKNLEKEKVDVVFGWARFNKDGNVEVQKRDNTTEVYSANHILVATGGKAIFPENIPG
FELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECI
QNTITDHYVKEGINVHKLSKIVKVEKNVETDKLKIHMNDSKSIDDVDELIWTIGRKSHLG
MGSENVGIKLNSHDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPE
KFRNDKLDYENVPSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKS
PTRYKIVCAGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELV
TMR
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| BDBM50060874 |
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| n/a |
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| Name | BDBM50060874 |
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| Synonyms: | 1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione | 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione | CHEMBL286494 | Hypericin | Hyperizin | hipericina | hypericine | hypericum red |
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| Type | Small organic molecule |
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| Emp. Form. | C30H16O8 |
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| Mol. Mass. | 504.4432 |
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| SMILES | Cc1cc(O)c2c3c1c1c(C)cc(O)c4c1c1c3c3c(c(O)cc(O)c3c2=O)c2c(O)cc(O)c(c12)c4=O |
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| Structure | 
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