Reaction Details |
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Target | C-X-C chemokine receptor type 4 |
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Ligand | BDBM50333890 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_700061 (CHEMBL1646838) |
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IC50 | 1.3±n/a nM |
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Citation | Skerlj, R; Bridger, G; McEachern, E; Harwig, C; Smith, C; Wilson, T; Veale, D; Yee, H; Crawford, J; Skupinska, K; Wauthy, R; Yang, W; Zhu, Y; Bogucki, D; Di Fluri, M; Langille, J; Huskens, D; De Clercq, E; Schols, D Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication. Bioorg Med Chem Lett21:262-6 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-X-C chemokine receptor type 4 |
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Name: | C-X-C chemokine receptor type 4 |
Synonyms: | C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor |
Type: | Enzyme |
Mol. Mass.: | 39754.61 |
Organism: | Homo sapiens (Human) |
Description: | P61073 |
Residue: | 352 |
Sequence: | MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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BDBM50333890 |
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n/a |
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Name | BDBM50333890 |
Synonyms: | CHEMBL1644092 | N-((1H-benzo[d]imidazol-2-yl)methyl)-N-((4-(aminomethyl)oxazol-5-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-amine |
Type | Small organic molecule |
Emp. Form. | C22H24N6O |
Mol. Mass. | 388.4656 |
SMILES | NCc1ncoc1CN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc12 |
Structure |
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