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TargetMitogen-activated protein kinase 8
LigandBDBM50334008
Substrate/Competitorn/a
Meas. Tech.ChEMBL_701207 (CHEMBL1648827)
IC50 1000±n/a nM
Citation Probst, GDBowers, SSealy, JMTruong, APHom, RKGalemmo, RAKonradi, AWSham, HLQuincy, DAPan, HYao, NLin, MTóth, GArtis, DRZmolek, WWong, KQin, ALorentzen, CNakamura, DFQuinn, KPSauer, JMPowell, KRuslim, LWright, SChereau, DRen, ZAnderson, JPBard, FYednock, TAGriswold-Prenner, I Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg Med Chem Lett21:315-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 8
Name:Mitogen-activated protein kinase 8
Synonyms:JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2)
Type:Enzyme
Mol. Mass.:48297.57
Organism:Homo sapiens (Human)
Description:JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:427
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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  Blast E-value cutoff:
BDBM50334008
n/a
NameBDBM50334008
Synonyms:3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one | CHEMBL1644618
TypeSmall organic molecule
Emp. Form.C23H23N5O
Mol. Mass.385.4616
SMILESO=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1
Structure
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