| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 |
|---|
| Ligand | BDBM50333996 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_701207 (CHEMBL1648827) |
|---|
| IC50 | 3800±n/a nM |
|---|
| Citation |  Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Tóth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg Med Chem Lett21:315-9 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 8 |
|---|
| Name: | Mitogen-activated protein kinase 8 |
|---|
| Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48297.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
|---|
| Residue: | 427 |
|---|
| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
|
|
|
|---|
| BDBM50333996 |
|---|
| n/a |
|---|
| Name | BDBM50333996 |
|---|
| Synonyms: | 4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-1,2,4-triazol-5(4H)-one | CHEMBL1644640 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H27N5O3 |
|---|
| Mol. Mass. | 457.5243 |
|---|
| SMILES | O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCOC1 |
|---|
| Structure | 
|
|---|
Search and Browse
