| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
|---|
| Ligand | BDBM50334164 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_698206 (CHEMBL1646511) |
|---|
| Ki | 6.8±n/a nM |
|---|
| Citation |  Maestrup, EG; Wiese, C; Schepmann, D; Brust, P; Wünsch, B Synthesis, pharmacological activity and structure affinity relationships of spirocyclics(1) receptor ligands with a (2-fluoroethyl) residue in 3-position. Bioorg Med Chem19:393-405 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sigma non-opioid intracellular receptor 1 |
|---|
| Name: | Sigma non-opioid intracellular receptor 1 |
|---|
| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 25307.17 |
|---|
| Organism: | Cavia porcellus (Guinea pig) |
|---|
| Description: | Q60492 |
|---|
| Residue: | 223 |
|---|
| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
|
|
|
|---|
| BDBM50334164 |
|---|
| n/a |
|---|
| Name | BDBM50334164 |
|---|
| Synonyms: | 2-[1'-(Cyclohexylmethyl)-3H-spiro[[2]benzofuran-1,4'-piperidin-3-yl])ethan-1-ol | CHEMBL1645208 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H31NO2 |
|---|
| Mol. Mass. | 329.4763 |
|---|
| SMILES | OCCC1OC2(CCN(CC3CCCCC3)CC2)c2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
