| Reaction Details |
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 | Report a problem with these data |
| Target | Bile acid receptor |
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| Ligand | BDBM50334246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_699400 (CHEMBL1647427) |
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| IC50 | 910±n/a nM |
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| Citation |  Richter, HG; Benson, GM; Blum, D; Chaput, E; Feng, S; Gardes, C; Grether, U; Hartman, P; Kuhn, B; Martin, RE; Plancher, JM; Rudolph, MG; Schuler, F; Taylor, S; Bleicher, KH Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia& diabetes. Bioorg Med Chem Lett21:191-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bile acid receptor |
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| Name: | Bile acid receptor |
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| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 55916.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96RI1 |
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| Residue: | 486 |
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| Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
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| BDBM50334246 |
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| n/a |
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| Name | BDBM50334246 |
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| Synonyms: | 2-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)-N-cyclohexyl-4-methylhexanamide | CHEMBL1642350 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32ClN3O |
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| Mol. Mass. | 438.005 |
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| SMILES | CCC(C)CC(C(=O)NC1CCCCC1)n1c(nc2ccccc12)-c1ccc(Cl)cc1 |
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| Structure | 
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