Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50334262 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_699426 (CHEMBL1647453) |
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Ki | 30.5±n/a nM |
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Citation | Nirogi, RV; Deshpande, AD; Kambhampati, R; Badange, RK; Kota, L; Daulatabad, AV; Shinde, AK; Ahmad, I; Kandikere, V; Jayarajan, P; Dubey, PK Indole-3-piperazinyl derivatives: novel chemical class of 5-HT(6) receptor antagonists. Bioorg Med Chem Lett21:346-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50334262 |
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n/a |
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Name | BDBM50334262 |
Synonyms: | 5-Chloro-1-(4-isopropylbenzenesulfonyl)-3-(4-ethylpiperazin-1-yl)-1H-indole | CHEMBL1642426 |
Type | Small organic molecule |
Emp. Form. | C23H28ClN3O2S |
Mol. Mass. | 446.005 |
SMILES | CCN1CCN(CC1)c1cn(c2ccc(Cl)cc12)S(=O)(=O)c1ccc(cc1)C(C)C |
Structure |
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