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TargetBeta-carbonic anhydrase 1
LigandBDBM16654
Substrate/Competitorn/a
Meas. Tech.ChEMBL_700107 (CHEMBL1646989)
Ki 356±n/a nM
Citation Pacchiano, FCarta, FVullo, DScozzafava, ASupuran, CT Inhibition ofß-carbonic anhydrases with ureido-substituted benzenesulfonamides. Bioorg Med Chem Lett21:102-5 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-carbonic anhydrase 1
Name:Beta-carbonic anhydrase 1
Synonyms:β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1
Type:Enzyme
Mol. Mass.:18186.06
Organism:Mycobacterium tuberculosis
Description:The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays.
Residue:163
Sequence:
MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAG
CVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESY
PDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
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BDBM16654
n/a
NameBDBM16654
Synonyms:1-phenyl-3-(4-sulfamoylphenyl)urea | aromatic sulfonamide compound 19
TypeSmall organic molecule
Emp. Form.C13H13N3O3S
Mol. Mass.291.326
SMILESNS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2)cc1
Structure
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