| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-carbonic anhydrase 1 |
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| Ligand | BDBM50334356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_700107 (CHEMBL1646989) |
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| Ki | 6.8±n/a nM |
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| Citation |  Pacchiano, F; Carta, F; Vullo, D; Scozzafava, A; Supuran, CT Inhibition ofß-carbonic anhydrases with ureido-substituted benzenesulfonamides. Bioorg Med Chem Lett21:102-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-carbonic anhydrase 1 |
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| Name: | Beta-carbonic anhydrase 1 |
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| Synonyms: | β-Carbonic anhydrase 1 (CA 1) | Carbonic Anhydrase (mtCA 1) | MTCA1_MYCTU | Uncharacterized protein Rv1284/MT1322 | canA | mtcA1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 18186.06 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | The recombinant GST-mtCA1 construct was cloned, expressed, and further purified from E. coli. The purified protein was used in inhibition assays. |
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| Residue: | 163 |
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| Sequence: | MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAG
CVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESY
PDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP
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| BDBM50334356 |
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| n/a |
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| Name | BDBM50334356 |
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| Synonyms: | 4-(3-(4-iodophenyl)ureido)benzenesulfonamide | 4-{[(4'-Iodophenyl)carbamoyl]amino}benzenesulfonamide | CHEMBL1643292 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12IN3O3S |
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| Mol. Mass. | 417.222 |
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| SMILES | NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(I)cc2)cc1 |
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| Structure | 
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