| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-6 |
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| Ligand | BDBM50334473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701134 (CHEMBL1648232) |
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| IC50 | 205±n/a nM |
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| Citation |  Zhang, Z; Zheng, G; Pivavarchyk, M; Deaciuc, AG; Dwoskin, LP; Crooks, PA Novel bis-, tris-, and tetrakis-tertiary amino analogs as antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. Bioorg Med Chem Lett21:88-91 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-6 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-6 |
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| Synonyms: | ACHA6_RAT | Acra6 | Chrna6 | Neuronal acetylcholine receptor protein alpha-6 subunit | Neuronal acetylcholine receptor subunit alpha-6 | Neuronal acetylcholine receptor subunit alpha-6/beta-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56943.53 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1454451 |
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| Residue: | 493 |
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| Sequence: | MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVT
VHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDI
VLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT
YDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLP
MFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVI
PLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLD
KTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTE
NSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVG
LFLQPLLGNTGAS
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| BDBM50334473 |
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| n/a |
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| Name | BDBM50334473 |
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| Synonyms: | 1,2,4,5-tetrakis(5-(3,4-dihydroisoquinolin-2(1H)-yl)pentyl)benzene | CHEMBL1643949 |
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| Type | Small organic molecule |
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| Emp. Form. | C62H82N4 |
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| Mol. Mass. | 883.3413 |
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| SMILES | C(CCN1CCc2ccccc2C1)CCc1cc(CCCCCN2CCc3ccccc3C2)c(CCCCCN2CCc3ccccc3C2)cc1CCCCCN1CCc2ccccc2C1 |
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| Structure | 
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