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TargetLysosomal alpha-glucosidase
LigandBDBM18358
Substrate/Competitorn/a
Meas. Tech.ChEMBL_701785 (CHEMBL1656922)
IC50 8000±n/a nM
Citation Ghisaidoobe, ABikker, Pde Bruijn, ACGodschalk, FDRogaar, EGuijt, MCHagens, PHalma, JMHart, SMLuitjens, SBvan Rixel, VHWijzenbroek, MZweegers, TDonker-Koopman, WEStrijland, ABoot, RMarel, GvOverkleeft, HSAerts, JM Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars ACS Med Chem Lett2:119-123 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysosomal alpha-glucosidase
Name:Lysosomal alpha-glucosidase
Synonyms:α-Glucosidase | Acid maltase | Gaa | LYAG_MOUSE | Lysosomal alpha-glucosidase | alpha-glucosidase (Gaa)
Type:Enzyme
Mol. Mass.:106235.32
Organism:Mus musculus (Mouse)
Description:P70699
Residue:953
Sequence:
MNIRKPLCSNSVVGACTLISLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQEG
YKPGPLHIQEQTEQPKEAPTQCDVPPSSRFDCAPDKGISQEQCEARGCCYVPAGQVLKEP
QIGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLH
FKIKDPASKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLF
FADQFLQLSTSLPSQHITGLGEHLSPLMLSTDWARITLWNRDTPPSQGTNLYGSHPFYLA
LEDGGLAHGVFLLNSNAMDVILQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGY
PFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDS
FADFPDMVRELHQDGRRYMMIVDPAISSAGPAGSYRPYDEGLRRGVFITNETGQPLIGKV
WPGTTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWLDMNEPSNFVRGSQQGCPNNELEN
PPYVPGVVGGILQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISR
STFSGHGRYAGHWTGDVRSSWEHLAYSVPDILQFNLLGVPLVGADICGFIGDTSEELCVR
WTQLGAFYPFMRNHNDLNSVPQEPYRFSETAQQAMRKAFALRYALLPYLYTLFHRAHVRG
DTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTEVTGYFPKGTWYNMQMVSV
DSLGTLPSPSSASSFRSAVQSKGQWLTLEAPLDTINVHLREGYIIPLQGPSLTTTESRKQ
PMALAVALTASGEADGELFWDDGESLAVLERGAYTLVTFSAKNNTIVNKLVRVTKEGAEL
QLREVTVLGVATAPTQVLSNGIPVSNFTYSPDNKSLAIPVSLLMGELFQISWS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM18358
n/a
NameBDBM18358
Synonyms:(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol | N-Nonyl-DNJ
TypeSmall organic molecule
Emp. Form.C15H31NO4
Mol. Mass.289.4109
SMILESCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Structure
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