| Reaction Details |
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 | Report a problem with these data |
| Target | Non-lysosomal glucosylceramidase |
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| Ligand | BDBM50335383 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701782 (CHEMBL1656919) |
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| IC50 | 15±n/a nM |
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| Citation |  Ghisaidoobe, A; Bikker, P; de Bruijn, AC; Godschalk, FD; Rogaar, E; Guijt, MC; Hagens, P; Halma, JM; Hart, SM; Luitjens, SB; van Rixel, VH; Wijzenbroek, M; Zweegers, T; Donker-Koopman, WE; Strijland, A; Boot, R; Marel, Gv; Overkleeft, HS; Aerts, JM Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars ACS Med Chem Lett2:119-123 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-lysosomal glucosylceramidase |
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| Name: | Non-lysosomal glucosylceramidase |
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| Synonyms: | Beta-glucosidase | GBA2 | GBA2_HUMAN | KIAA1605 | SPG46 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 104639.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1435476 |
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| Residue: | 927 |
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| Sequence: | MGTQDPGNMGTGVPASEQISCAKEDPQVYCPEETGGTKDVQVTDCKSPEDSRPPKETDCC
NPEDSGQLMVSYEGKAMGYQVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLR
YLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMY
QHRTVIADQFTVCLRREGQTVYQQVLSLERPSVLRSWNWGLCGYFAFYHALYPRAWTVYQ
LPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDD
APGGLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQ
QVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFG
AKGQVHYRRYTRFFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSAL
FNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVH
FYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDD
EPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDK
DHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILS
RGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVR
ALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWE
GFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKASW
PKVKQGTGLRTGPMFGPKEAMANLSPE
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| BDBM50335383 |
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| n/a |
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| Name | BDBM50335383 |
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| Synonyms: | CHEMBL1651637 | N-Heptoxypentyl-L-ido-1-deoxynojirimycin |
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| Type | Small organic molecule |
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| Emp. Form. | C18H37NO5 |
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| Mol. Mass. | 347.4901 |
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| SMILES | CCCCCCCOCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO |r| |
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| Structure | 
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