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TargetNon-lysosomal glucosylceramidase
LigandBDBM18358
Substrate/Competitorn/a
Meas. Tech.ChEMBL_701782 (CHEMBL1656919)
IC50 7±n/a nM
Citation Ghisaidoobe, ABikker, Pde Bruijn, ACGodschalk, FDRogaar, EGuijt, MCHagens, PHalma, JMHart, SMLuitjens, SBvan Rixel, VHWijzenbroek, MZweegers, TDonker-Koopman, WEStrijland, ABoot, RMarel, GvOverkleeft, HSAerts, JM Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars ACS Med Chem Lett2:119-123 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Non-lysosomal glucosylceramidase
Name:Non-lysosomal glucosylceramidase
Synonyms:Beta-glucosidase | GBA2 | GBA2_HUMAN | KIAA1605 | SPG46
Type:PROTEIN
Mol. Mass.:104639.04
Organism:Homo sapiens (Human)
Description:ChEMBL_1435476
Residue:927
Sequence:
MGTQDPGNMGTGVPASEQISCAKEDPQVYCPEETGGTKDVQVTDCKSPEDSRPPKETDCC
NPEDSGQLMVSYEGKAMGYQVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLR
YLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMY
QHRTVIADQFTVCLRREGQTVYQQVLSLERPSVLRSWNWGLCGYFAFYHALYPRAWTVYQ
LPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDD
APGGLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQ
QVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFG
AKGQVHYRRYTRFFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSAL
FNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVH
FYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDD
EPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDK
DHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILS
RGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVR
ALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWE
GFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKASW
PKVKQGTGLRTGPMFGPKEAMANLSPE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM18358
n/a
NameBDBM18358
Synonyms:(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol | N-Nonyl-DNJ
TypeSmall organic molecule
Emp. Form.C15H31NO4
Mol. Mass.289.4109
SMILESCCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Structure
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