| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
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| Ligand | BDBM50336000 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_717060 (CHEMBL1671178) |
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| Ki | 104±n/a nM |
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| Citation |  Burch, JD; Farand, J; Colucci, J; Sturino, C; Ducharme, Y; Friesen, RW; Lévesque, JF; Gagné, S; Wrona, M; Therien, AG; Mathieu, MC; Denis, D; Vigneault, E; Xu, D; Clark, P; Rowland, S; Han, Y Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor. Bioorg Med Chem Lett21:1041-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP4 subtype |
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| Name: | Prostaglandin E2 receptor EP4 subtype |
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| Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 53134.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35408 |
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| Residue: | 488 |
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| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
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| BDBM50336000 |
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| n/a |
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| Name | BDBM50336000 |
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| Synonyms: | 2-(2-methoxyphenyl)-N-(3-methyl-4-(1-oxo-4,9-bis(2,2,2-trifluoroethoxy)-1H-benzo[f]isoindol-2(3H)-yl)phenethyl)acetamide | CHEMBL1669021 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H30F6N2O5 |
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| Mol. Mass. | 660.6028 |
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| SMILES | COc1ccccc1CC(=O)NCCc1ccc(N2Cc3c(C2=O)c(OCC(F)(F)F)c2ccccc2c3OCC(F)(F)F)c(C)c1 |
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| Structure | 
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