| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
|---|
| Ligand | BDBM50335982 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_717059 |
|---|
| Ki | 0.32±n/a nM |
|---|
| Citation |  Burch JD; Farand J; Colucci J; Sturino C; Ducharme Y; Friesen RW; Lévesque JF; Gagné S; Wrona M; Therien AG; Mathieu MC; Denis D; Vigneault E; Xu D; Clark P; Rowland S; Han Y Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor. Bioorg Med Chem Lett 21:1041-6 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin E2 receptor EP4 subtype |
|---|
| Name: | Prostaglandin E2 receptor |
|---|
| Synonyms: | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostanoid EP4 receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53134.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35408 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
|
|
|
|---|
| BDBM50335982 |
|---|
| n/a |
|---|
| Name | BDBM50335982 |
|---|
| Synonyms: | 2-(2-chlorophenyl)-N-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[f]isoindol-2(3H)-yl)-3-methylbenzyl)cyclopropyl)acetamide | CHEMBL1669015 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H35ClN2O4 |
|---|
| Mol. Mass. | 583.116 |
|---|
| SMILES | CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)Cc2ccccc2Cl)cc1C |
|---|
| Structure | 
|
|---|
Search and Browse
