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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Insulin-like growth factor 1 receptor | ||
| Ligand | BDBM50336322 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_716595 (CHEMBL1670374) | ||
| IC50 | 6±n/a nM | ||
| Citation |  Jin, M; Kleinberg, A; Cooke, A; Gokhale, PC; Foreman, K; Dong, H; Siu, KW; Bittner, MA; Mulvihill, KM; Yao, Y; Landfair, D; O'Connor, M; Mak, G; Pachter, JA; Wild, R; Rosenfeld-Franklin, M; Ji, Q; Mulvihill, MJ Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy. Bioorg Med Chem Lett21:1176-80 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Insulin-like growth factor 1 receptor | |||
| Name: | Insulin-like growth factor 1 receptor | ||
| Synonyms: | CD_antigen=CD221 | IGF-I receptor | IGF1R | IGF1R_HUMAN | Insulin-like growth factor 1 receptor (IGF1R) | Insulin-like growth factor 1 receptor (IGFIR) | Insulin-like growth factor 1 receptor alpha chain | Insulin-like growth factor 1 receptor beta chain | Insulin-like growth factor I receptor | Insulin-like growth factor receptor (IGFR) | ||
| Type: | Protein | ||
| Mol. Mass.: | 154776.79 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08069 | ||
| Residue: | 1367 | ||
| Sequence: |
| ||
| BDBM50336322 | |||
| n/a | |||
| Name | BDBM50336322 | ||
| Synonyms: | CHEMBL1667940 | trans-4-(8-amino-1-(8-fluoro-2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)cyclohexanecarboxamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H25FN6O | ||
| Mol. Mass. | 480.5361 | ||
| SMILES | NC(=O)[C@H]1CC[C@@H](CC1)c1nc(-c2ccc3ccc(nc3c2F)-c2ccccc2)c2c(N)nccn12 |r,wU:6.9,wD:3.2,(26.07,-41.48,;24.53,-41.46,;23.74,-42.79,;24.05,-40,;25.07,-38.85,;24.6,-37.38,;23.09,-37.08,;22.06,-38.22,;22.54,-39.68,;22.6,-35.62,;23.5,-34.37,;22.59,-33.12,;23.36,-31.8,;22.59,-30.47,;23.36,-29.14,;24.9,-29.13,;25.67,-27.81,;27.2,-27.81,;27.97,-29.14,;27.2,-30.47,;25.67,-30.47,;24.9,-31.8,;25.67,-33.14,;29.5,-29.14,;30.27,-30.48,;31.81,-30.48,;32.58,-29.14,;31.8,-27.8,;30.27,-27.81,;21.13,-33.61,;19.79,-32.84,;19.79,-31.3,;18.46,-33.62,;18.46,-35.16,;19.79,-35.93,;21.13,-35.15,)| | ||
| Structure | 
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