| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
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| Ligand | BDBM50336342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_716691 (CHEMBL1670516) |
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| IC50 | 16400±n/a nM |
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| Citation |  Choi, E; Lee, C; Park, JE; Seo, JJ; Cho, M; Kang, JS; Kim, HM; Park, SK; Lee, K; Han, G Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors. Bioorg Med Chem Lett21:1218-21 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| BDBM50336342 |
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| n/a |
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| Name | BDBM50336342 |
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| Synonyms: | CHEMBL1668018 | N-hydroxy-3-(1-(3-(naphthalen-2-yl)propyl)-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)propanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N2O3 |
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| Mol. Mass. | 338.4003 |
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| SMILES | ONC(=O)CCC1=CCN(CCCc2ccc3ccccc3c2)C1=O |t:6| |
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| Structure | 
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