| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 51(CYP51) |
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| Ligand | BDBM31773 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_721239 |
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| Kd | 200±n/a nM |
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| Citation |  Warrilow AG; Jackson CJ; Parker JE; Marczylo TH; Kelly DE; Lamb DC; Kelly SL Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae. Antimicrob Agents Chemother 53:1157-64 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 51(CYP51) |
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| Name: | Cytochrome P450 51(CYP51) |
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| Synonyms: | CYPLI | Lanosterol 14-alpha demethylase | P450-14DM | P450-LIA1 | Sterol 14-alpha demethylase |
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| Type: | Monooxygenase; oxidoreductase |
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| Mol. Mass.: | 50869.67 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | The recombinant Mbt CYP51 expressed in E. coli was used in binding assay. |
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| Residue: | 451 |
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| Sequence: | MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANE
FFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ
VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLA
YVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPR
FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA
LRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFP
DPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMA
QPPESYRNDHSKMVVQLAQPACVRYRRRTGV
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| BDBM31773 |
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| n/a |
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| Name | BDBM31773 |
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| Synonyms: | ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pevaryl | cid_68589 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15Cl3N2O |
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| Mol. Mass. | 381.684 |
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| SMILES | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 |
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| Structure | 
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