| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
|---|
| Ligand | BDBM25259 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_724759 (CHEMBL1676999) |
|---|
| Ki | 6900±n/a nM |
|---|
| Citation |  Singh, AP; Zhang, Y; No, JH; Docampo, R; Nussenzweig, V; Oldfield, E Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth. Antimicrob Agents Chemother54:2987-93 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Geranylgeranyl pyrophosphate synthase |
|---|
| Name: | Geranylgeranyl pyrophosphate synthase |
|---|
| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
|---|
| Type: | Homooctamer; transferase |
|---|
| Mol. Mass.: | 34867.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
|---|
| Residue: | 300 |
|---|
| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
|
|
|
|---|
| BDBM25259 |
|---|
| n/a |
|---|
| Name | BDBM25259 |
|---|
| Synonyms: | 3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphonoethyl)pyridin-1-ium | Bisphpshonate-715 | bisphosphonate, 15 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H31NO7P2 |
|---|
| Mol. Mass. | 423.3781 |
|---|
| SMILES | CCCCCCCCCCOc1ccc[n+](CC(P(O)(O)=O)P(O)([O-])=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
