| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
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| Ligand | BDBM50336506 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_724759 (CHEMBL1676999) |
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| Ki | 3300±n/a nM |
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| Citation |  Singh, AP; Zhang, Y; No, JH; Docampo, R; Nussenzweig, V; Oldfield, E Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth. Antimicrob Agents Chemother54:2987-93 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl pyrophosphate synthase |
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| Name: | Geranylgeranyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
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| Type: | Homooctamer; transferase |
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| Mol. Mass.: | 34867.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
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| Residue: | 300 |
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| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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| BDBM50336506 |
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| n/a |
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| Name | BDBM50336506 |
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| Synonyms: | 2-(decyl(methyl)amino)ethane-1,1-diyldiphosphonic acid | Bisphpshonate-943 | CHEMBL1673218 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H31NO6P2 |
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| Mol. Mass. | 359.3359 |
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| SMILES | CCCCCCCCCCN(C)CC(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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