| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-lactamase |
|---|
| Ligand | BDBM50336510 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_723551 (CHEMBL1676791) |
|---|
| Ki | 180±n/a nM |
|---|
| Citation |  Ishii, Y; Eto, M; Mano, Y; Tateda, K; Yamaguchi, K In vitro potentiation of carbapenems with ME1071, a novel metallo-beta-lactamase inhibitor, against metallo-beta-lactamase- producing Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother54:3625-9 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-lactamase |
|---|
| Name: | Beta-lactamase |
|---|
| Synonyms: | Beta-lactamase | metallo-beta-lactamase IMP-1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 27125.88 |
|---|
| Organism: | Pseudomonas aeruginosa |
|---|
| Description: | gi_27368096 |
|---|
| Residue: | 246 |
|---|
| Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
|
|
|
|---|
| BDBM50336510 |
|---|
| n/a |
|---|
| Name | BDBM50336510 |
|---|
| Synonyms: | 7,8-dihydroxy-1-methoxy-3-methyl-10-oxo-1,10-dihydropyrano[4,3-b]chromene-9-carboxylic acid | CHEMBL1673300 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H12O8 |
|---|
| Mol. Mass. | 320.251 |
|---|
| SMILES | COC1OC(C)=Cc2oc3cc(O)c(O)c(C(O)=O)c3c(=O)c12 |c:5| |
|---|
| Structure | 
|
|---|
Search and Browse
