| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol 14a-demethylase |
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| Ligand | BDBM50127138 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_724295 (CHEMBL1677688) |
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| Kd | 31±n/a nM |
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| Citation |  Warrilow, AG; Melo, N; Martel, CM; Parker, JE; Nes, WD; Kelly, SL; Kelly, DE Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B. Antimicrob Agents Chemother54:4225-34 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol 14a-demethylase |
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| Name: | Lanosterol 14a-demethylase |
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| Synonyms: | 14-alpha sterol demethylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58939.22 |
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| Organism: | Neosartorya fumigata |
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| Description: | ChEMBL_724288 |
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| Residue: | 524 |
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| Sequence: | MGLIAFILDGICKHCSTQSTWVLVGIGLLSILAVSVIINVLQQLLFKNPHEPPVVFHWFP
FIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCAEE
VYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAF
QGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYHNLDMGFAPINFMLPWAP
LPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLMSCVYKNGTPVPDEEIAHM
MIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHA
KVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWN
PHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVL
VRLFRFRNLPGVDGIPDTDYSSLFSKPLGRSFVEFEKRESATKA
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| BDBM50127138 |
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| n/a |
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| Name | BDBM50127138 |
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| Synonyms: | 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one | CHEMBL22587 | ITRACONAZOLE | Itrizole (TN) | Oriconazole | Sporanox (TN) |
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| Type | Small organic molecule |
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| Emp. Form. | C35H38Cl2N8O4 |
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| Mol. Mass. | 705.633 |
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| SMILES | CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(OC[C@H]3CO[C@@](Cn4cncn4)(O3)c3ccc(Cl)cc3Cl)cc2)c1=O |r| |
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| Structure | 
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