| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50336564 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_725391 (CHEMBL1676914) |
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| Ki | 3.9±n/a nM |
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| Citation |  Abate, C; Niso, M; Lacivita, E; Mosier, PD; Toscano, A; Perrone, R Analogues ofs receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers. J Med Chem54:1022-32 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50336564 |
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| n/a |
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| Name | BDBM50336564 |
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| Synonyms: | (+)-(R)-1-Cyclohexyl-4-[2-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yloxy)ethyl]piperazine | CHEMBL1672038 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H36N2O2 |
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| Mol. Mass. | 372.5441 |
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| SMILES | COc1cccc2[C@@H](CCCc12)OCCN1CCN(CC1)C1CCCCC1 |r| |
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| Structure | 
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