| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM50336581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_725602 (CHEMBL1677785) |
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| Ki | 122±n/a nM |
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| Citation |  Zhang, Z; Wu, G; Xie, F; Song, T; Chang, X 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies. J Med Chem54:1101-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM50336581 |
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| n/a |
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| Name | BDBM50336581 |
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| Synonyms: | CHEMBL1672072 | N,N-dimethylamino-3-(4-N,N-dimethylaminophenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile |
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| Type | Small organic molecule |
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| Emp. Form. | C23H15N3O2 |
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| Mol. Mass. | 365.3841 |
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| SMILES | CN(C)c1ccc(Oc2ccc3c4c(C#N)c(=O)nc4c4cccc2c34)cc1 |
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| Structure | 
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