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TargetDelta-type opioid receptor
LigandBDBM50336601
Substrate/Competitorn/a
Meas. Tech.ChEMBL_725804 (CHEMBL1678400)
EC50 0.690000±n/a nM
Citation Spetea, MWindisch, PGuo, YBileviciute-Ljungar, ISchütz, JAsim, MFBerzetei-Gurske, IPRiba, PKiraly, KFürst, SAl-Khrasani, MSchmidhammer, H Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies. J Med Chem54:980-8 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Delta-type opioid receptor
Name:Delta-type opioid receptor
Synonyms:D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40382.98
Organism:Homo sapiens (Human)
Description:Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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  Blast E-value cutoff:
BDBM50336601
n/a
NameBDBM50336601
Synonyms:CHEMBL3216476 | [[17-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-14beta-[(3-phenylpropyl)oxy]morphinan-6beta-yl]amino]acetic Acid Dihydrochloride
TypeSmall organic molecule
Emp. Form.C31H40Cl2N2O5
Mol. Mass.591.566
SMILESCl.Cl.[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]5(CC[C@@H]2NCC(O)=O)OCCCc1ccccc1)ccc3O |r,TLB:12:11:19:6.7.8|
Structure
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