| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50336595 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_725617 (CHEMBL1677800) |
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| Ki | 1±n/a nM |
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| Citation |  Spetea, M; Windisch, P; Guo, Y; Bileviciute-Ljungar, I; Schütz, J; Asim, MF; Berzetei-Gurske, IP; Riba, P; Kiraly, K; Fürst, S; Al-Khrasani, M; Schmidhammer, H Synthesis and pharmacological activities of 6-glycine substituted 14-phenylpropoxymorphinans, a novel class of opioids with high opioid receptor affinities and antinociceptive potencies. J Med Chem54:980-8 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50336595 |
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| n/a |
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| Name | BDBM50336595 |
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| Synonyms: | CHEMBL1672087 | tert-butyl 2-{[(1S,5R,13R,14R,17S)-10-hydroxy-4-methyl-17-(3-phenylpropoxy)-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-yl]amino}acetate |
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| Type | Small organic molecule |
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| Emp. Form. | C32H42N2O5 |
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| Mol. Mass. | 534.6863 |
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| SMILES | CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@]3(CC[C@H]4NCC(=O)OC(C)(C)C)OCCCc1ccccc1)ccc5O |r| |
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| Structure | 
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