Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50336602 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_725831 (CHEMBL1678427) |
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Ki | 183±n/a nM |
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Citation | Cheng, K; Lee, YS; Rothman, RB; Dersch, CM; Bittman, RW; Jacobson, AE; Rice, KC Probes for narcotic receptor mediated phenomena. 41. Unusual inverseµ-agonists and potentµ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans. J Med Chem54:957-69 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50336602 |
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n/a |
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Name | BDBM50336602 |
Synonyms: | 3-((1S,5R)-2-(((1'S,2'S)-2-Phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol hydrochloride | CHEMBL1672183 |
Type | Small organic molecule |
Emp. Form. | C24H29NO |
Mol. Mass. | 347.4932 |
SMILES | Oc1cccc(c1)[C@]12CCC[C@H](C1)N(C[C@H]1C[C@@H]1c1ccccc1)CC2 |r| |
Structure |
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