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TargetEndothelin receptor ET-A
LigandBDBM50336698
Substrate/Competitorn/a
Meas. Tech.ChEMBL_723169
Ki 7.3±n/a nM
Citation Michel KBüther KLaw MPWagner SSchober OHermann SSchäfers MRiemann BHöltke CKopka K Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography. J Med Chem 54:939-48 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelin receptor ET-A
Name:Endothelin receptor ET-A
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:48591.87
Organism:Mus musculus
Description:ChEMBL_723169
Residue:427
Sequence:
MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERS
SHKDSMN
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  Blast E-value cutoff:
BDBM50336698
n/a
NameBDBM50336698
Synonyms:CHEMBL1672885 | N-[1-(2-{2-[2-(2-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3-ylmethyl]-2,3-dimethoxyphenoxy}ethoxy)ethoxy]ethoxy}ethyl)-1H-1,2,3-triazol-4-ylmethyl]-4-fluorobenzenesulfonamide
TypeSmall organic molecule
Emp. Form.C44H47FN4O14S
Mol. Mass.906.926
SMILESCOc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OCCOCCOCCOCCn2cc(CNS(=O)(=O)c3ccc(F)cc3)nn2)c1)c1ccc2OCOc2c1 |c:14|
Structure
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