| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50336699 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_723169 (CHEMBL1675391) |
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| Ki | 3.9±n/a nM |
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| Citation |  Michel, K; Büther, K; Law, MP; Wagner, S; Schober, O; Hermann, S; Schäfers, M; Riemann, B; Höltke, C; Kopka, K Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography. J Med Chem54:939-48 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_MOUSE | Ednra | Endothelin receptor ET-A | Gpcr10 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48591.87 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_723169 |
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| Residue: | 427 |
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| Sequence: | MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERS
SHKDSMN
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| BDBM50336699 |
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| n/a |
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| Name | BDBM50336699 |
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| Synonyms: | CHEMBL1672884 | N-[1-(2-{2-[2-(2-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3-ylmethyl]-2,3-dimethoxyphenoxy}ethoxy)ethoxy]ethoxy}ethyl)-1H-1,2,3-triazol-4-ylmethyl]-4-fluoro-N-methylbenzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C45H49FN4O14S |
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| Mol. Mass. | 920.952 |
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| SMILES | COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OCCOCCOCCOCCn2cc(CN(C)S(=O)(=O)c3ccc(F)cc3)nn2)c1)c1ccc2OCOc2c1 |c:14| |
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| Structure | 
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